Chronic pain relief new treatments are finally giving hope to approximately 100 million people in the United States who suffer from chronic pain. For decades, opioids have been the go-to solution for severe pain management, despite their significant risks including overdose and misuse. However, exciting developments are changing this landscape.
Fortunately, the FDA recently approved Journavx (suzetrigine), a first-in-class non-opioid analgesic for treating moderate to severe acute pain in adults. This breakthrough represents a significant shift in pain relief alternatives, especially considering studies show opioids are no more effective than alternative treatments for chronic pain management. Additionally, we’re seeing a growing focus on the strongest non opioid painkiller options as the economic burden of chronic pain exceeds that of diabetes, cardiovascular conditions, and even cancer. In this article, we’ll explore these modern approaches to pain management that offer effective relief without the devastating risk of addiction.
Understanding Severe Pain and Its Challenges
Pain isn’t simply a one-dimensional experience. The sensation we call “pain” stems from complex communications between our nerves, spinal cord, and brain, creating different types of discomfort based on underlying causes and duration.
Types of pain: acute vs chronic
Acute pain acts as the body’s alarm system—sudden, intense, and usually with a clear cause. This type typically lasts fewer than 6 months and diminishes once the underlying issue resolves. Common triggers include broken bones, surgery, dental procedures, labor, cuts, and burns. For most people, acute pain follows a predictable pattern: sharp intensity that gradually improves as healing occurs.
In contrast, chronic pain persists beyond the expected healing time, typically lasting more than three months. This form of ongoing discomfort affects approximately 40% of older adults in America and impacts one in five U.S. adults overall. Furthermore, about one in fourteen adults experiences “high-impact” chronic pain—discomfort that significantly limits life or work activities.
Chronic pain manifests in several forms:
- Nociceptive pain comes from tissue damage and inflammation, commonly seen in osteoarthritis
- Neuropathic pain results from nerve damage, as with diabetic neuropathy or shingles
- Nociplastic pain arises from altered pain processing without clear tissue damage, as in fibromyalgia
The economic burden is staggering—chronic pain costs the United States between $560 billion and $635 billion annually in medical expenses, lost productivity, and disability programs.
Why opioids became the default
Opioids initially became standard treatment because they effectively relieve many types of acute pain while improving function. Before the late 1990s, these powerful medications were primarily reserved for acute trauma, perioperative care, cancer pain, and end-of-life care.
During the 1980s, certain pain specialists began advocating for long-term opioid therapy—first for cancer pain, then for severe chronic pain—arguing this approach was the more ethical choice to help patients regain quality of life. Subsequently, pharmaceutical companies promoted the message that patients with severe pain would not become addicted to prescription opioids.
As a result, opioid prescribing increased fourfold between 1999 and 2010. By 2014, U.S. retail pharmacies dispensed 245 million prescriptions for opioid pain relievers. Presently, opioids remain the most commonly prescribed medication class in America.
The risks of long-term opioid use
Despite their widespread use, evidence supporting opioids for long-term pain management remains limited. More concerning are the substantial risks that increase with higher doses and longer duration.
The most serious risk is overdose. Patients recently prescribed opioids face an overdose rate of 256 per 100,000 person-years—over seven times higher than those not using these medications. Moreover, this danger increases dramatically with higher doses. Compared to low doses (1-19 mg morphine equivalents daily), doses exceeding 100 mg daily raise overdose risk nearly ninefold.
Addiction represents another significant concern. Although approximately 8-12% of patients develop opioid use disorder, the risk rises dramatically with prolonged use. Patients receiving opioids for more than 90 days at higher doses become over 100 times more likely to develop opioid use disorder than non-users.
Other documented risks include hormonal disruptions affecting fertility and sexual function, increased risk of myocardial infarction, motor vehicle accidents, and respiratory depression. These dangers, coupled with limited evidence of long-term effectiveness, have prompted medical professionals to reconsider opioids as the default approach to chronic pain management.
The Biopsychosocial Model in Pain Management
For decades, medical approaches to severe pain focused primarily on biological factors. Nevertheless, recent advances have revealed that effective pain management requires a much broader perspective. Enter the biopsychosocial model—a framework that’s reshaping how we understand and treat chronic pain.
What is the biopsychosocial model?
The biopsychosocial model represents a holistic approach to understanding health and illness, acknowledging the intricate interplay between biological, psychological, and social factors. Developed by George Engel in 1977, this model moved beyond the reductionist viewpoint that solely concentrates on physiological aspects. Instead, it recognizes pain as more than a sensation—it encompasses suffering that requires treating the whole person rather than just focusing on where they hurt.
At its core, the biopsychosocial model posits that pain is the result of complex interactions between:
- Biological factors: Tissue damage, nerve signals, inflammation
- Psychological factors: Emotions, thoughts, behaviors, coping strategies
- Social factors: Relationships, support systems, cultural context, economic factors
Unlike the traditional biomedical model that assumes a direct relationship between tissue damage and pain, the biopsychosocial approach describes pain as a multidimensional, dynamic integration among physiological, psychological, and social factors that reciprocally influence one another.
How it changes treatment planning
Adopting this model fundamentally transforms how we approach pain management. Rather than exclusively relying on the pathophysiology involved in nociception, treatment planning shifts to include the patient’s cognitive and emotional state, psychological vulnerability, and conditioned responses that influence their pain experiences.
In fact, studies show that psychological factors heavily influence pain perception. Depression, anxiety, catastrophic thinking, pain self-efficacy, and overall mental health all significantly affect symptom intensity and functional disability following treatment. Social factors like support networks, cultural traditions, and economic conditions likewise play crucial roles.
Consequently, treatment planning under this model involves:
- Integrating various therapeutic modalities within a comprehensive framework
- Developing personalized approaches based on individual biopsychosocial profiles
- Moving beyond medication-only approaches to include psychological and social interventions
- Utilizing multidisciplinary teams including physicians, psychologists, physical therapists, and social workers
This approach acknowledges that for any given nociception, a complex interplay of factors together influence the pain a patient experiences. Fundamentally, this means pain is more than just a physical sensory experience—it’s a personal journey shaped by numerous interconnected elements.
Assessing physical, mental, and social factors
A comprehensive biopsychosocial assessment looks beyond the traditional “where does it hurt?” questions. To gain the best understanding of how chronic pain develops, how it’s maintained, and its functional consequences, information about all three domains must be gathered and integrated.
Physical assessment typically includes:
- Pain location, intensity, and quality
- Physical functioning and limitations
- Biological mechanisms of pain (neuropathic, nociceptive, nociplastic)
Psychological assessment examines:
- Emotional responses like anxiety, depression, and catastrophizing
- Pain-related fear and avoidance behaviors
- Self-efficacy and coping strategies
Social assessment considers:
- Family dynamics and support systems
- Work environment and economic factors
- Cultural influences and access to resources
Obviously, this assessment approach requires more time than simply prescribing medication. Yet, evidence spanning over 30 years confirms that psychosocial factors are inherent in chronic pain and require evaluation if meaningful diagnostics and treatments are to occur.
Interestingly, factors perceived as safe or reassuring are largely social and psychological in origin. This underscores the vital importance of building therapeutic alliances between patients and healthcare providers—where patients feel understood, their pain experience validated, and treatment approaches are collaboratively designed.
Modern Non-Opioid Medications for Pain Relief
Expanding our medical toolkit beyond opioids has become essential in tackling severe pain effectively. Modern medications offer promising alternatives without the risk of addiction that accompanies traditional opioid treatments.
NSAIDs and acetaminophen
NSAIDs (nonsteroidal anti-inflammatory drugs) function by blocking cyclooxygenase enzymes that produce pain-causing prostaglandins. Common options include ibuprofen, naproxen, and aspirin. Acetaminophen (Tylenol), though not an NSAID, reduces pain through central nervous system effects.
For acute musculoskeletal pain, diclofenac Emulgel demonstrates remarkable effectiveness with 78% of users experiencing at least 50% pain relief compared to 20% with placebo. Simultaneously, ketoprofen gel (72% effective vs. 33% placebo) and piroxicam gel (70% vs. 47%) offer additional options.
Notably, taking acetaminophen alongside an NSAID may provide equivalent pain relief with lower doses of both medications, minimizing side effects. Nevertheless, these medications carry risks—NSAIDs can cause gastrointestinal issues and increase cardiovascular risk at high doses, whereas acetaminophen can damage the liver if exceeding 3,000 mg daily.
Antidepressants and anticonvulsants
These medications primarily target nerve pain by affecting neurotransmitters. Tricyclic antidepressants will relieve one in every 2-3 patients with peripheral neuropathic pain, whereas serotonin noradrenaline reuptake inhibitors help one in every 4-5 patients.
Secondly, anticonvulsants like gabapentin and pregabalin inhibit calcium channels that release pain neurotransmitters. Recent systematic reviews strongly recommend gabapentin for neuropathic pain, backed by high-quality evidence.
New pain medication: Journavx and its mechanism
FDA-approved in 2025, Journavx (suzetrigine) represents a breakthrough as the first non-opioid analgesic in a new class. This innovative medication reduces pain by targeting Nav1.8 sodium channels in the peripheral nervous system before pain signals reach the brain.
Clinical trials demonstrated statistically significant pain reduction compared to placebo following surgeries. Actually, Journavx does not cause addiction because it works outside the central nervous system.
Topical treatments and muscle relaxants
Topical treatments provide localized relief without systemic side effects. For instance, diclofenac gel showed superior efficacy compared to placebo in multiple studies. Lidocaine patches (up to 5% concentration) effectively relieve nerve pain after shingles.
Muscle relaxants like carisoprodol, cyclobenzaprine, and methocarbamol affect muscle function primarily as central nervous system depressants.
Strongest non opioid painkiller options
Among non-opioid options, combination therapies often provide the strongest relief. Indeed, clinical evidence suggests NSAIDs combined with acetaminophen can offer additive pain-relieving activity. For neuropathic pain, high-concentration capsaicin patches demonstrated 33% effectiveness versus 24% for placebo.
The recent development of Journavx represents an important advancement, offering relief comparable to opioids without addiction risk.
Non-Pharmacologic Pain Relief Alternatives
Beyond medications, modern pain management increasingly embraces non-drug approaches that show remarkable effectiveness without the risks associated with pharmaceuticals.
Physical therapy and exercise
Physical therapy offers targeted interventions that both decrease pain and improve function. Through guided movement, patients can restore mobility, build strength, and regain confidence. Research shows that physical activity interrupts the “vicious cycle” of pain and reduced mobility often seen in conditions like arthritis and fibromyalgia.
Physical therapy methods typically include:
- Low-impact aerobic training to improve cardiovascular health
- Strengthening exercises for supporting muscles around painful areas
- Pain relief exercises targeting specific conditions
- Stretching to enhance flexibility and reduce stiffness
Certainly, physical therapy isn’t just about exercises. Many practitioners employ heat and ice applications, massage, and joint mobilization techniques. One study noted that physical therapy encompasses “infinite possibilities” to modify programs ensuring patient comfort while facilitating progress.
TENS and electrical stimulation
Transcutaneous electrical nerve stimulation (TENS) uses low-voltage electrical currents to relieve pain. These small battery-powered devices deliver alternating current via cutaneous electrodes positioned near painful areas. TENS works through two primary mechanisms—either by stimulating nerve cells that block pain signal transmission or by raising endorphin levels (the body’s natural pain-killers).
Clinical evidence supports TENS for treating numerous conditions including osteoarthritis, tendinitis, fibromyalgia, and diabetic neuropathy. Importantly, research indicates that using the strongest comfortable intensity produces optimal hypoalgesia effects.
Mindfulness and cognitive behavioral therapy
Mindfulness-based interventions (MBIs) show impressive results for chronic pain management. By cultivating nonjudgmental, nonreactive awareness of present-moment experiences, patients develop acceptance-based pain coping skills.
Similarly, cognitive behavioral therapy (CBT) teaches active self-management by adaptively changing behaviors, cognitions, and emotional responses. A major randomized clinical trial with 770 adults found both approaches significantly improved pain, function, and quality of life while reducing opioid dosage over 12 months.
Acupuncture and massage
Acupuncture involves inserting thin needles at specified points on the body. Studies demonstrate acupuncture’s effectiveness for various pain conditions with particularly strong evidence for postsurgical pain relief, showing 21% opioid reduction at 8 hours and up to 29% at 72 hours post-surgery.
Therapeutic massage manipulates the body’s soft tissues through kneading, rubbing, and stroking. A landmark randomized clinical trial comparing acupuncture and massage for cancer pain found both treatments provided long-term pain reduction without significant differences between approaches. The study showed both therapies improved not only pain but also fatigue, insomnia, and quality of life over 26 weeks.
Interventional and Advanced Therapies
When conventional therapies fall short, interventional pain procedures offer precise relief without addiction risks. These minimally invasive techniques target pain at its source through various specialized approaches.
Joint and nerve block injections
Nerve blocks deliver local anesthetic medications near specific nerves to temporarily interrupt pain transmission. These targeted injections can both diagnose pain sources and provide relief. Different types address specific pain locations—from genicular nerve blocks for knee pain to trigeminal blocks for facial pain. Primarily, these procedures allow many patients to avoid surgery entirely. For chronic conditions, nerve blocks can provide relief lasting weeks or even months.
Epidural steroid injections
Epidural steroid injections (ESIs) deliver anti-inflammatory medication into the epidural space around spinal nerves. Used extensively for radicular pain, herniated disks, and spinal stenosis, these outpatient procedures typically provide relief for three months or longer. Remarkably, ESIs help approximately 50% of patients experience significant pain improvement.
Radiofrequency ablation
Radiofrequency ablation (RFA) uses heat from radio waves to disable specific nerves and block pain signals. Unlike temporary blocks, RFA can provide relief lasting 6-24 months. The procedure specifically targets medial branch nerves along spinal joints, interrupting pain communication without affecting surrounding healthy tissue.
Spinal cord stimulation and neuromodulation
Spinal cord stimulation implants deliver mild electrical pulses that disrupt pain signals before they reach the brain. This advanced therapy helps manage conditions including failed back surgery syndrome and complex regional pain syndrome, with over 50% of patients experiencing significant improvement. As a fourth-line treatment before opioids, neuromodulation has expanded to treat axial back pain, peripheral neuropathy, and post-surgical pain syndromes.
Conclusion
Pain management has undoubtedly evolved beyond the one-dimensional opioid approach that dominated treatment for decades. Modern approaches now address the complex nature of pain through multiple avenues while prioritizing patient safety. Effective pain relief without addiction risk is finally becoming a reality rather than just a hope.
The biopsychosocial model stands at the center of this transformation, recognizing that pain encompasses biological, psychological, and social dimensions. This comprehensive framework allows healthcare providers to develop personalized treatment plans that target all aspects of a patient’s pain experience.